EP300 and MTOR

Number of citations of the paper that reports this interaction (PubMedID 29033323)
14

Data Source:
BioGRID (enzymatic study)

		EP300	MTOR
Description		E1A binding protein p300	mechanistic target of rapamycin kinase
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Transcription Factor Complex Chromosome Cytosol Protein-DNA Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane PML Body Dendrite TORC1 Complex TORC2 Complex Neuronal Cell Body Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity, Transferring Acyl Groups Chromatin DNA Binding Activating Transcription Factor Binding Nuclear Hormone Receptor Binding Tau Protein Binding Androgen Receptor Binding NF-kappaB Binding Peptide-lysine-N-acetyltransferase Activity Protein Propionyltransferase Activity Pre-mRNA Intronic Binding STAT Family Protein Binding Peptide Butyryltransferase Activity Histone Crotonyltransferase Activity Histone Butyryltransferase Activity	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Ribosome Binding Translation Regulator Activity Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Somitogenesis Thigmotaxis Behavioral Defense Response Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Glycolytic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Protein Acetylation Internal Protein Amino Acid Acetylation Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Nervous System Development Heart Development Skeletal Muscle Tissue Development Learning Or Memory Circadian Rhythm Animal Organ Morphogenesis Regulation Of Autophagy Macrophage Derived Foam Cell Differentiation Regulation Of Mitochondrion Organization Positive Regulation Of Neuron Projection Development Viral Process Histone Acetylation Protein Deubiquitination N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation B Cell Differentiation Platelet Formation Lung Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Complex Assembly Protein Destabilization Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Cellular Response To UV Multicellular Organism Growth Megakaryocyte Development Swimming Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Estrogen Positive Regulation By Host Of Viral Transcription Histone H4 Acetylation Histone H2B Acetylation Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Face Morphogenesis Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Peptidyl-lysine Propionylation Regulation Of Tubulin Deacetylation Peptidyl-lysine Crotonylation Peptidyl-lysine Butyrylation Regulation Of Cellular Response To Heat Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Signal Transduction By P53 Class Mediator Beta-catenin-TCF Complex Assembly Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Regulation Of Cell Growth Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Regulation Of Glycogen Biosynthetic Process Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Protein Phosphorylation Cell Cycle Arrest Germ Cell Development Brain Development Cell Aging Response To Nutrient Long-term Memory Regulation Of Cell Size Visual Learning Cellular Response To Starvation Post-embryonic Development Negative Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Positive Regulation Of Neuron Maturation Negative Regulation Of Muscle Atrophy Response To Activity Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Spinal Cord Development Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Ruffle Organization Regulation Of Myelination Response To Nutrient Levels Cellular Response To Nutrient Levels TOR Signaling Regulation Of Fatty Acid Beta-oxidation Regulation Of Response To Food Activation Of Protein Kinase B Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Insulin Regulation Of Actin Cytoskeleton Organization Cellular Response To Amino Acid Starvation Social Behavior Multicellular Organism Growth TORC1 Signaling Wound Healing Response To Cocaine Regulation Of Circadian Rhythm Regulation Of GTPase Activity Response To Amino Acid Anoikis Response To Morphine Regulation Of Carbohydrate Utilization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase III Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process MRNA Stabilization Rhythmic Process Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Voluntary Musculoskeletal Movement Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Cardiac Muscle Contraction Maternal Process Involved In Female Pregnancy Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Dendritic Spine Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Cellular Response To Hypoxia Regulation Of Brown Fat Cell Differentiation Regulation Of Membrane Permeability Regulation Of Translation At Synapse, Modulating Synaptic Transmission Regulation Of Cellular Response To Heat Positive Regulation Of Neuron Death Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Eating Behavior Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Negative Regulation Of Cholangiocyte Apoptotic Process Positive Regulation Of Granulosa Cell Proliferation Positive Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Iodide Transmembrane Transport Positive Regulation Of Cytoplasmic Translational Initiation Cellular Response To Leucine Starvation
Pathways		Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression RORA activates gene expression Polo-like kinase mediated events Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock Circadian Clock B-WICH complex positively regulates rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling Metalloprotease DUBs Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation	PIP3 activates AKT signaling Macroautophagy mTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs			Pimecrolimus Sirolimus Everolimus AP1903 SF1126 XL765 Temsirolimus
Diseases		Rubinstein-Taybi syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22936669) General risk tolerance (MTAG) ( 30643258) Neuroticism ( 29255261) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30297969)	Beard thickness ( 26926045) Body mass index ( 25673413) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591)
Interacting Genes		372 interacting genes: ABL1 ACSM5 ACTA2 ACTB AHR AKT1 ALKBH4 ALX1 APEX1 AR ARHGDIA ARNT ARNTL ARSF ASCL1 ASH2L ATF4 ATF5 ATR AUTS2 BAG6 BCAS2 BCL3 BCL6 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDK1 CDK2 CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLOCK CNOT4 COPS2 COPS6 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DDX5 DECR2 DEK DTX1 DUX4 E2F1 E2F5 EEF1A1 EEF2 EGR1 EID1 EID2 ELF3 ELK1 EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO3 FOXP3 GAA GABPA GATA2 GATA4 GATA5 GATA6 GCKR GLUL GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B H1-1 H1-3 H2AC20 H2AC21 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4-16 H4C14 H4C9 HAND2 HBP1 HDAC1 HDAC3 HDAC6 HEMGN HERC1 HIF1A HIPK2 HMGB1 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P ILF2 ILF3 IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KLF1 KLF13 KLF2 KLF4 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCL1 MCM2 MCM3 MCM3AP MCM4 MCM5 MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MGMT MITF MN1 MORF4L1 MPG MRE11 MSH6 MSTO1 MTOR MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEIL2 NEUROD1 NFATC1 NFATC2 NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR1I2 NR2F2 NR4A1 NUP98 NUPR1 OLIG2 ORC2 PAK2 PAX5 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POLI POU3F2 PPARA PPARD PPP2R5C PRKCA PRKCB PRKCD PRKDC PRMT1 PROX1 PTMA RACK1 RAD23A RAD50 RAN RB1 RBM14 RBX1 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 RUVBL2 SATB1 SAV1 SELENOP SENP3 SERTAD1 SET SETD1A SIRT1 SIRT2 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNAI1 SNIP1 SNW1 SOX9 SP1 SP3 SPHK1 SPIB SREBF1 SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUMO2 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBC UBE2D1 UBE2I UBQLN1 UBTF USF2 VPS18 WDR59 WDR82 XRCC6 YWHAZ YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB49 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF148 ZNF76 ZRANB2	52 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 GPHN GSK3B HRAS IRS1 MAF1 MLST8 NRAS PA2G4 PDPK1 PLD2 PPP2R2A PREX1 PRKAA1 PRKCA PRR5L RHEB RHEBL1 RICTOR RPS6KA1 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 UVRAG WIPI2 YWHAQ ZNRF2
Entrez ID		2033	2475
HPRD ID		04078	03134
Ensembl ID		ENSG00000100393	ENSG00000198793
Uniprot IDs		Q09472 Q7Z6C1	P42345
PDB IDs		1L3E 1P4Q 2K8F 2MH0 2MZD 3BIY 3I3J 3IO2 3P57 3T92 4BHW 4PZR 4PZS 4PZT 5BT3 5KJ2 5LKT 5LKU 5LKX 5LKZ 5LPK 5LPM 5NU5 5XZC 6DS6 6FGN 6FGS 6GYR 6GYT 6K4N 6PF1 6PGU	1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6SB0 6SB2
Enriched GO Terms of Interacting Partners?
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