KLHL12 and TTBK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KLHL12	TTBK2
Description		kelch like family member 12	tau tubulin kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Extracellular Space Nucleus Cytoplasm Centriole Cytosol Ciliary Transition Zone Ciliary Basal Body
	Molecular Function	Protein Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Tau Protein Binding Tau-protein Kinase Activity Microtubule Plus-end Binding
	Biological Process	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Cerebellum Development Cerebellar Granular Layer Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Protein Localization To Microtubule Negative Regulation Of Microtubule Binding
Pathways		Degradation of DVL	Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Bipolar disorder ( 31043756) MGMT methylation in smokers ( 26183928)
Interacting Genes		46 interacting genes: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL2 DVL3 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 MTNR1A NDC80 NTAQ1 PDGFRB PEA15 PEF1 PRR13 RIT1 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 ZBP1	1 interacting genes: KLHL12
Entrez ID		59349	146057
HPRD ID		13925	10288
Ensembl ID		ENSG00000117153	ENSG00000128881
Uniprot IDs		Q53G59 Q9H7R2	Q6IQ55 Q8IWY7
PDB IDs		2VPJ
Enriched GO Terms of Interacting Partners?
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