NDRG2 and CLN8

Number of citations of the paper that reports this interaction (PubMedID 23142642)
4

Data Source:
BioGRID (two hybrid)

		NDRG2	CLN8
Description		NDRG family member 2	CLN8 transmembrane ER and ERGIC protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding Ceramide Binding
	Biological Process	Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Vascular Endothelial Growth Factor Production Wnt Signaling Pathway Substantia Nigra Development Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Platelet-derived Growth Factor Production	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Nervous System Development Cholesterol Metabolic Process Lipid Biosynthetic Process Protein Catabolic Process Negative Regulation Of Proteolysis Ceramide Biosynthetic Process
Pathways
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Heart rate response to exercise ( 29769521) Hip circumference adjusted for BMI ( 28552196) Metabolite levels (small molecules and protein measures) ( 27005778) Resting heart rate ( 27798624)	Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		6 interacting genes: ATP1B1 CLN8 CTDP1 MOB2 RABAC1 TRIM32	29 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUP1
Entrez ID		57447	2055
HPRD ID		17630	06383
Ensembl ID		ENSG00000165795	ENSG00000182372
Uniprot IDs		Q9UN36	A0A024QZ57 Q9UBY8
PDB IDs		2XMQ 2XMR 2XMS
Enriched GO Terms of Interacting Partners?
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