CLN8 and MTX1

Number of citations of the paper that reports this interaction (PubMedID 23142642)
4

Data Source:
BioGRID (two hybrid)

		CLN8	MTX1
Description		CLN8 transmembrane ER and ERGIC protein	metaxin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Mitochondrial Sorting And Assembly Machinery Complex Integral Component Of Membrane
	Molecular Function	Protein Binding Ceramide Binding
	Biological Process	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Nervous System Development Cholesterol Metabolic Process Lipid Biosynthetic Process Protein Catabolic Process Negative Regulation Of Proteolysis Ceramide Biosynthetic Process	Lactation Protein Transport
Pathways			Mitochondrial protein import Cristae formation
Drugs
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Blood urea nitrogen levels ( 31152163) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462 31451708) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866) General risk tolerance (MTAG) ( 30643258) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Inflammatory bowel disease ( 28067908) Red blood cell count ( 27863252) Renal function-related traits (BUN) ( 22797727) Serum cancer antigen 15.3 levels ( 31666285) Urate levels ( 31578528) Urea levels ( 28270201)
Interacting Genes		29 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUP1	3 interacting genes: CLN8 MTX2 TOMM40
Entrez ID		2055	4580
HPRD ID		06383	11861
Ensembl ID		ENSG00000182372	ENSG00000173171
Uniprot IDs		A0A024QZ57 Q9UBY8	Q13505
PDB IDs
Enriched GO Terms of Interacting Partners?
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