PAK5 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PAK5	CRBN
Description		p21 (RAC1) activated kinase 5	cereblon
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Synapse	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Cell Proliferation Cell Migration Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Activation of RAC1
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		21 interacting genes: ARMC7 ATPAF2 BAD CARD9 CCNG1 CDC42 CRBN EMD EXOSC1 FHL3 GCC1 INKA1 LENG1 LZTS2 PDLIM7 PRPF31 PSMF1 RAC1 SORBS3 TUBGCP4 UXT	33 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		57144	51185
HPRD ID		06423	16750
Ensembl ID		ENSG00000101349	ENSG00000113851
Uniprot IDs		B0AZM9 Q9P286	Q96SW2
PDB IDs		2F57	4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G
Enriched GO Terms of Interacting Partners?
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