PAK5 and EMD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PAK5	EMD
Description		p21 (RAC1) activated kinase 5	emerin
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Synapse	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Spindle Microtubule Membrane Integral Component Of Membrane Spindle Pole Centrosome Nuclear Membrane Cortical Endoplasmic Reticulum
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Actin Binding Protein Binding Cadherin Binding Beta-tubulin Binding
	Biological Process	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Cell Proliferation Cell Migration Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Muscle Contraction Mitotic Nuclear Envelope Reassembly Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Activation of RAC1	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases			Emery-Dreifuss muscular dystrophy
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)
Interacting Genes		21 interacting genes: ARMC7 ATPAF2 BAD CARD9 CCNG1 CDC42 CRBN EMD EXOSC1 FHL3 GCC1 INKA1 LENG1 LZTS2 PDLIM7 PRPF31 PSMF1 RAC1 SORBS3 TUBGCP4 UXT	45 interacting genes: ABL1 ABT1 ACTB ACTG2 AEN AKAP8L BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CEP70 COPS6 CREB3 CTNNBIP1 DPPA4 EFHC2 FATE1 GMCL1 KASH5 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 MEOX2 MTNR1A PAK5 PSME1 RNF123 SH3GL2 SH3GL3 SRC STX4 SYNE1 TRAF3IP3 TRIM42 VAPB VAV1 YTHDC1 ZFP64 ZNF165 ZNF232
Entrez ID		57144	2010
HPRD ID		06423	02309
Ensembl ID		ENSG00000101349	ENSG00000102119
Uniprot IDs		B0AZM9 Q9P286	P50402
PDB IDs		2F57	1JEI 2ODC 2ODG 6GHD
Enriched GO Terms of Interacting Partners?
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