RTN4 and CHMP6

		RTN4	CHMP6
Description		reticulon 4	charged multivesicular body protein 6
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GO Annotations	Cellular Component	Cell Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Cell Junction Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane	ESCRT III Complex Cell Cytosol Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Protein Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Axonogenesis Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve	Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Protein Catabolic Process Midbody Abscission Regulation Of Exosomal Secretion ESCRT III Complex Assembly
Pathways		Axonal growth inhibition (RHOA activation)	Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Obesity (extreme) ( 19553259) Systolic blood pressure ( 30224653)
Interacting Genes		42 interacting genes: BAIAP2 BCL2 BCL2L1 CERT1 CGREF1 CHMP6 CLN8 CNTNAP1 CRMP1 FXR2 GLP1R HLA-DPB1 IPP LAMA4 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 NRXN1 NSD1 PLEKHF2 POT1 PPP1R21 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 STON1 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	8 interacting genes: CHMP4A CHMP4B ELOF1 METTL9 RTN4 SNF8 VPS25 VPS36
Entrez ID		57142	79643
HPRD ID		07259	08564
Ensembl ID		ENSG00000115310	ENSG00000176108
Uniprot IDs		Q9NQC3	Q96FZ7
PDB IDs		2G31 2JV5	2K3W 3HTU
Enriched GO Terms of Interacting Partners?
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