CHMP6 and CHMP4B

Number of citations of the paper that reports this interaction (PubMedID 16730941)
60

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CHMP6	CHMP4B
Description		charged multivesicular body protein 6	charged multivesicular body protein 4B
Image
GO Annotations	Cellular Component	ESCRT III Complex Cell Cytosol Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome	ESCRT III Complex Cell Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Cytoplasmic Side Of Plasma Membrane Membrane Coat Midbody Late Endosome Membrane Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Protein-containing Complex Binding Protein N-terminus Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Protein Catabolic Process Midbody Abscission Regulation Of Exosomal Secretion ESCRT III Complex Assembly	Mitotic Cytokinesis Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Exit From Mitosis Regulation Of Centrosome Duplication Endosomal Transport Macroautophagy Viral Life Cycle Nuclear Envelope Reassembly Multivesicular Body Assembly Maintenance Of Lens Transparency Viral Budding Via Host ESCRT Complex Viral Budding Regulation Of Viral Process Protein Polymerization Negative Regulation Of Cell Death Midbody Abscission Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Neuron Death Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Autophagosome Assembly
Pathways		Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III	Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS			Feeling nervous ( 29500382) Loneliness ( 27629369) Offspring birth weight ( 31043758) Stearic acid (18:0) levels ( 23362303)
Interacting Genes		8 interacting genes: CHMP4A CHMP4B ELOF1 METTL9 RTN4 SNF8 VPS25 VPS36	15 interacting genes: CHMP1B CHMP3 CHMP4A CHMP4C CHMP5 CHMP6 EXOSC9 HIPK2 NOD2 PDCD6IP PIAS2 PTPN23 STAMBP UBE2I VPS4A
Entrez ID		79643	128866
HPRD ID		08564	16642
Ensembl ID		ENSG00000176108	ENSG00000101421
Uniprot IDs		Q96FZ7	Q9H444
PDB IDs		2K3W 3HTU	3C3Q 3UM3 4ABM 5MK2
Enriched GO Terms of Interacting Partners?
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