RTN4 and UQCRC2

Number of citations of the paper that reports this interaction (PubMedID 12067236)
20

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RTN4	UQCRC2
Description		reticulon 4	ubiquinol-cytochrome c reductase core protein 2
Image
GO Annotations	Cellular Component	Cell Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Cell Junction Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Mitochondrial Respiratory Chain Complex IV Mitochondrial Processing Peptidase Complex
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Axonogenesis Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Protein Processing Involved In Protein Targeting To Mitochondrion Aerobic Respiration Response To Drug
Pathways		Axonal growth inhibition (RHOA activation)	Respiratory electron transport
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE FAMOXADONE METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE UBIQUINONE-2
Diseases
GWAS		Obesity (extreme) ( 19553259) Systolic blood pressure ( 30224653)
Interacting Genes		42 interacting genes: BAIAP2 BCL2 BCL2L1 CERT1 CGREF1 CHMP6 CLN8 CNTNAP1 CRMP1 FXR2 GLP1R HLA-DPB1 IPP LAMA4 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 NRXN1 NSD1 PLEKHF2 POT1 PPP1R21 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 STON1 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	3 interacting genes: CACNA1A RTN4 UQCRC1
Entrez ID		57142	7385
HPRD ID		07259	01876
Ensembl ID		ENSG00000115310	ENSG00000140740
Uniprot IDs		Q9NQC3	P22695
PDB IDs		2G31 2JV5	5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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