FBXL8 and ORC4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FBXL8	ORC4
Description		F-box and leucine rich repeat protein 8	origin recognition complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol SCF Ubiquitin Ligase Complex	Nuclear Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Cell Cycle	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS			Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: ORC4 SKP1	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4
Entrez ID		55336	5000
HPRD ID		16430	09118
Ensembl ID		ENSG00000135722	ENSG00000115947
Uniprot IDs		Q96CD0	A8K7H4 O43929 Q96B14
PDB IDs			5UJ7 5UJM
Enriched GO Terms of Interacting Partners?
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