MED18 and USP49

Number of citations of the paper that reports this interaction (PubMedID 12584197)
20

Data Source:
HPRD (in vitro, in vivo)

		MED18	USP49
Description		mediator complex subunit 18	ubiquitin specific peptidase 49
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mediator Complex Core Mediator Complex	Nucleoplasm
	Molecular Function	Transcription Coregulator Activity Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Histone Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Termination Of RNA Polymerase II Transcription	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Ub-specific processing proteases
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)	Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 23263863 20139978 27863252) Red blood cell count ( 20139978 27863252) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		7 interacting genes: CAMK2B HOMEZ MED20 MED31 MED9 TRIM39 USP49	9 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 RBCK1 STING1 TP53 TRIM35
Entrez ID		54797	25862
HPRD ID		17476	10075
Ensembl ID		ENSG00000130772	ENSG00000164663
Uniprot IDs		Q9BUE0	Q70CQ1
PDB IDs
Enriched GO Terms of Interacting Partners?
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