USP49 and MED17

Number of citations of the paper that reports this interaction (PubMedID 14576168)
16

Data Source:
HPRD (in vivo)

		USP49	MED17
Description		ubiquitin specific peptidase 49	mediator complex subunit 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Histone Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Ub-specific processing proteases	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 23263863 20139978 27863252) Red blood cell count ( 20139978 27863252) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		9 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 RBCK1 STING1 TP53 TRIM35	16 interacting genes: BCL6 CTDP1 ESR1 ESR2 HEMGN HNF4A MED19 MED22 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49
Entrez ID		25862	9440
HPRD ID		10075	04816
Ensembl ID		ENSG00000164663	ENSG00000042429
Uniprot IDs		Q70CQ1	Q9NVC6
PDB IDs
Enriched GO Terms of Interacting Partners?
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