DCUN1D1 and UBE2M

Number of citations of the paper that reports this interaction (PubMedID 30803229)
2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		DCUN1D1	UBE2M
Description		defective in cullin neddylation 1 domain containing 1	ubiquitin conjugating enzyme E2 M
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytosol	Nucleoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation	Cellular Protein Modification Process Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation
Pathways		Neddylation	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK - noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		25 interacting genes: ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CUL5 DAZAP2 DVL2 LAPTM5 LZTS2 MAP3K1 NEDD4 RHOA RNF11 SMAD2 TLE5 TP53BP2 TRIM39 TRIM54 UBC UBE2D3 UBE2F UBE2M VPS37B	28 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA3
Entrez ID		54165	9040
HPRD ID		12067	04414
Ensembl ID		ENSG00000043093	ENSG00000130725
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	A0A024R4T4 P61081
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W	1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?
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