MBD3 and TET1

Number of citations of the paper that reports this interaction (PubMedID 22196727)
203

Data Source:
BioGRID (pull down)

		MBD3	TET1
Description		methyl-CpG binding domain protein 3	tet methylcytosine dioxygenase 1
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GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex	Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	DNA Binding Iron Ion Binding Zinc Ion Binding Methyl-CpG Binding Methylcytosine Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator	Inner Cell Mass Cell Differentiation 5-methylcytosine Catabolic Process Chromatin Organization Protein O-linked Glycosylation Positive Regulation Of Cell Proliferation Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Negative Regulation Of Methylation-dependent Chromatin Silencing
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS			Chronotype ( 30696823) Height ( 31562340) Pulse pressure ( 30224653) Triglycerides ( 30275531)
Interacting Genes		29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277	2 interacting genes: DDX21 MBD3
Entrez ID		53615	80312
HPRD ID		04653	09694
Ensembl ID		ENSG00000071655	ENSG00000138336
Uniprot IDs		O95983	Q8NFU7
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	6ASD
Enriched GO Terms of Interacting Partners?
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