MBD3 and KDM5B

Number of citations of the paper that reports this interaction (PubMedID 21937684)
47

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MBD3	KDM5B
Description		methyl-CpG binding domain protein 3	lysine demethylase 5B
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GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) Histone Binding Dioxygenase Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Single Fertilization Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Oxidation-reduction Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Response To Fungicide Uterus Morphogenesis Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Estradiol Secretion
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors
Drugs
Diseases
GWAS
Interacting Genes		29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277	5 interacting genes: FOXG1 KDM1A MBD3 PAX9 RB1
Entrez ID		53615	10765
HPRD ID		04653	09251
Ensembl ID		ENSG00000071655	ENSG00000117139
Uniprot IDs		O95983	A0A3B3ITA8 Q9UGL1
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV	2MA5 2MNY 2MNZ 5A1F 5A3N 5A3P 5A3T 5A3W 5FPL 5FPU 5FUN 5FUP 5FV3 5FY4 5FY5 5FY9 5FYB 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5LW9 5LWB 6EIN 6EIU 6EIY 6EJ0 6EJ1 6EK6 6H4Z 6H50 6H51 6H52
Enriched GO Terms of Interacting Partners?
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