MBD3 and BCL11B

Number of citations of the paper that reports this interaction (PubMedID 16091750)
68

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		MBD3	BCL11B
Description		methyl-CpG binding domain protein 3	BAF chromatin remodeling complex subunit BCL11B
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex	Nucleus Neuron Projection
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator	Keratinocyte Development Epithelial Cell Morphogenesis Regulation Of Transcription, DNA-templated Multicellular Organism Development Negative Regulation Of Cell Proliferation Regulation Of Keratinocyte Proliferation Regulation Of Lipid Metabolic Process Striatal Medium Spiny Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Post-embryonic Camera-type Eye Development T Cell Differentiation In Thymus T Cell Receptor V(D)J Recombination Hematopoietic Stem Cell Migration Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive T Cell Selection Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Thymus Development Olfactory Bulb Axon Guidance Lymphoid Lineage Cell Migration Into Thymus
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Airway wall thickness ( 25517131) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic stiffness ( 22068335) Bipolar disorder ( 31043756) Corneal curvature ( 22969067) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Metabolite levels ( 23823483) Schizophrenia ( 28991256 25056061 29483656 30285260) Staphylococcus aureus infection ( 24847357) Systolic blood pressure night-to-day ratio in hypertension ( 29973135)
Interacting Genes		29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277	9 interacting genes: CBX5 MBD3 MTA2 NR2F1 NR2F2 RBBP4 RBBP7 SP1 SUV39H1
Entrez ID		53615	64919
HPRD ID		04653	05950
Ensembl ID		ENSG00000071655	ENSG00000127152
Uniprot IDs		O95983	L8B567 L8B7P7 L8B862 L8B8F6 Q9C0K0
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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