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PLN and EDA
Number of citations of the paper that reports this interaction (PubMedID
25910212
)
127
Data Source:
BioGRID
(two hybrid)
PLN
EDA
Description
phospholamban
ectodysplasin A
Image
GO Annotations
Cellular Component
Cell
Mitochondrion
Endoplasmic Reticulum
Membrane
Mitochondrial Membrane
Vesicle
Sarcoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Calcium Ion-transporting ATPase Complex
Extracellular Region
Collagen Trimer
Endoplasmic Reticulum Membrane
Lipid Droplet
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Integral Component Of Membrane
Intracellular Membrane-bounded Organelle
Apical Part Of Cell
Molecular Function
Enzyme Inhibitor Activity
Calcium Channel Regulator Activity
Protein Binding
ATPase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
ATPase Binding
Signaling Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Biological Process
Regulation Of The Force Of Heart Contraction
Calcium Ion Transport
Notch Signaling Pathway
Blood Circulation
Regulation Of Heart Contraction
Response To Zinc Ion
Negative Regulation Of Heart Rate
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Negative Regulation Of ATPase Activity
Response To Insulin
Response To Testosterone
Negative Regulation Of Catalytic Activity
Cardiac Muscle Tissue Development
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Calcium Ion Transport
Negative Regulation Of Calcium Ion Transport
Relaxation Of Cardiac Muscle
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Cardiac Muscle Cell Contraction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process
Regulation Of Cardiac Muscle Cell Membrane Potential
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Binding
Regulation Of Calcium-transporting ATPase Activity
Negative Regulation Of Calcium-transporting ATPase Activity
Regulation Of Relaxation Of Cardiac Muscle
Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Immune Response
Cell-matrix Adhesion
Gene Expression
Positive Regulation Of Gene Expression
Cell Differentiation
Tumor Necrosis Factor-mediated Signaling Pathway
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pigmentation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Salivary Gland Cavitation
Hair Follicle Placode Formation
Trachea Gland Development
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of NIK/NF-kappaB Signaling
Pathways
Ion homeostasis
Ion transport by P-type ATPases
TNFs bind their physiological receptors
Drugs
Diseases
Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
Tooth agenesis; Hypodontia
GWAS
Atrial fibrillation (
28416818
30061737
)
Cardiac structure and function (
19584346
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
27659466
)
QT interval (
23166209
24952745
19305408
19305409
19587794
)
Resting heart rate (
27798624
)
Male-pattern baldness (
30573740
)
Metabolite levels (
23823483
)
Monobrow (
27182965
)
Primary tooth development (number of teeth) (
23704328
20195514
)
Primary tooth development (time to first tooth eruption) (
23704328
20195514
)
Tooth agenesis (maxillary lateral incisors) (
29364747
)
Interacting Genes
14 interacting genes:
ATP2A1
ATP2A2
BCL2L13
CREB3
CREB3L1
DMPK
DVL3
EDA
LDLRAD1
PPP1R3A
PRKACA
S100A1
SLN
TMEM79
15 interacting genes:
ATP6V0C
CYB561
DOLK
EDA2R
EDAR
EMP3
FURIN
GIMAP5
LEPROTL1
MAL
NIPAL3
OSTC
OSTCP1
PLN
SEC22A
Entrez ID
5350
1896
HPRD ID
01395
02347
Ensembl ID
ENSG00000198523
ENSG00000158813
Uniprot IDs
P26678
Q5R352
A0A0U5J797
Q92838
PDB IDs
1K9N
1KCH
1PLN
1PLP
1PSL
1ZLL
2HYN
1RJ7
1RJ8
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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