EDA and DOLK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EDA	DOLK
Description		ectodysplasin A	dolichol kinase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Signaling Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding	Dolichol Kinase Activity Protein Binding
	Biological Process	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Dolichyl Diphosphate Biosynthetic Process Phosphorylation Dolichyl Monophosphate Biosynthetic Process
Pathways		TNFs bind their physiological receptors	Synthesis of Dolichyl-phosphate Defective DOLK causes DOLK-CDG (CDG-1m)
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia	Congenital disorders of glycosylation (CDG) type I
GWAS		Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		15 interacting genes: ATP6V0C CYB561 DOLK EDA2R EDAR EMP3 FURIN GIMAP5 LEPROTL1 MAL NIPAL3 OSTC OSTCP1 PLN SEC22A	4 interacting genes: CREB3 EDA KCNA3 UBQLN1
Entrez ID		1896	22845
HPRD ID		02347	15525
Ensembl ID		ENSG00000158813	ENSG00000175283
Uniprot IDs		A0A0U5J797 Q92838	A0A0S2Z597 Q9UPQ8
PDB IDs		1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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