EDA and LEPROTL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EDA	LEPROTL1
Description		ectodysplasin A	leptin receptor overlapping transcript like 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Endosome Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding
	Biological Process	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Protein Localization To Cell Surface
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		15 interacting genes: ATP6V0C CYB561 DOLK EDA2R EDAR EMP3 FURIN GIMAP5 LEPROTL1 MAL NIPAL3 OSTC OSTCP1 PLN SEC22A	4 interacting genes: EDA KLRG1 LMNA MSR1
Entrez ID		1896	23484
HPRD ID		02347	09551
Ensembl ID		ENSG00000158813	ENSG00000104660
Uniprot IDs		A0A0U5J797 Q92838	O95214 Q6FHL7
PDB IDs		1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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