PLCB3 and TRPM7

Number of citations of the paper that reports this interaction (PubMedID 11941371)
177

Data Source:
BioGRID (pull down)

		PLCB3	TRPM7
Description		phospholipase C beta 3	transient receptor potential cation channel subfamily M member 7
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol	Ruffle Cell Plasma Membrane Integral Component Of Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding	Actin Binding Protein Serine/threonine Kinase Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Trisphosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol	Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Protein Autophosphorylation Protein Tetramerization Necroptotic Process Calcium Ion Transmembrane Transport
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	TRP channels
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester 1,4-Dithiothreitol
Diseases
GWAS		Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Calcium levels ( 29403010) Chronic obstructive pulmonary disease ( 30804561) Household income (MTAG) ( 31844048) Pulse pressure ( 27841878) QT interval ( 24952745) Systolic blood pressure ( 27841878)
Interacting Genes		13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7	9 interacting genes: ANXA1 EEF2 H3-4 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6
Entrez ID		5331	54822
HPRD ID		02577	10418
Ensembl ID		ENSG00000149782	ENSG00000092439
Uniprot IDs		Q01970	A0A024R5V1 H0YLN8 Q96QT4
PDB IDs		3OHM 4GNK 4QJ3 4QJ4 4QJ5
Enriched GO Terms of Interacting Partners?
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