PLCB3 and PARD6A

Number of citations of the paper that reports this interaction (PubMedID 15782111)
7

Data Source:
HPRD (in vivo)

		PLCB3	PARD6A
Description		phospholipase C beta 3	par-6 family cell polarity regulator alpha
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding	Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding GTP-dependent Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Trisphosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cellular Localization Bicellular Tight Junction Assembly Positive Regulation Of Protein Localization To Centrosome
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7	26 interacting genes: APP ATP5MG CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		5331	50855
HPRD ID		02577	06316
Ensembl ID		ENSG00000149782	ENSG00000102981
Uniprot IDs		Q01970	Q9NPB6
PDB IDs		3OHM 4GNK 4QJ3 4QJ4 4QJ5	1WMH
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?