PKP1 and GTF2IRD1

Number of citations of the paper that reports this interaction (PubMedID 26275350)
6

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PKP1	GTF2IRD1
Description		plakophilin 1	GTF2I repeat domain containing 1
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GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Desmosome Ficolin-1-rich Granule Membrane Messenger Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Epidermis Cadherin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Cell-cell Junction Assembly Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Keratinization Neutrophil Degranulation Intermediate Filament Bundle Assembly Cornification Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Multicellular Organism Development Transition Between Slow And Fast Fiber
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases		Ectodermal dysplasia/skin fragility syndrome
GWAS		Panic disorder ( 19165232)	Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Severe influenza A (H1N1) infection ( 26379185) SjÃ¶gren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469)
Interacting Genes		9 interacting genes: DSC1 DSG1 DSP GTF2IRD1 KRT14 KRT8 TNS2 UCHL5 VIM	22 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
Entrez ID		5317	9569
HPRD ID		03579	08379
Ensembl ID		ENSG00000081277	ENSG00000006704
Uniprot IDs		A0A024R952 Q13835	E9PFE2 Q9UHL9
PDB IDs		1XM9	2D99 2DN5 2DZQ 2DZR
Enriched GO Terms of Interacting Partners?
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