PKP1 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 21800051)
8

Data Source:
BioGRID (pull down)

		PKP1	UCHL5
Description		plakophilin 1	ubiquitin C-terminal hydrolase L5
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Desmosome Ficolin-1-rich Granule Membrane Messenger Ribonucleoprotein Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ino80 Complex
	Molecular Function	Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Epidermis Cadherin Binding	RNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding
	Biological Process	Cell-cell Junction Assembly Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Keratinization Neutrophil Degranulation Intermediate Filament Bundle Assembly Cornification Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process	DNA Repair DNA Recombination Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases		Ectodermal dysplasia/skin fragility syndrome
GWAS		Panic disorder ( 19165232)	Cannabis dependence ( 21668797)
Interacting Genes		9 interacting genes: DSC1 DSG1 DSP GTF2IRD1 KRT14 KRT8 TNS2 UCHL5 VIM	101 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		5317	51377
HPRD ID		03579	10293
Ensembl ID		ENSG00000081277	ENSG00000116750
Uniprot IDs		A0A024R952 Q13835	Q9Y5K5
PDB IDs		1XM9	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?
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