PI3 and KRT1

Number of citations of the paper that reports this interaction (PubMedID 8999895)
28

Data Source:
BioGRID (pull down)

		PI3	KRT1
Description		peptidase inhibitor 3	keratin 1
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytosol Extracellular Matrix	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Epidermis	Protein Binding Carbohydrate Binding Structural Constituent Of Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Copulation Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Antimicrobial Humoral Response Cornification	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification
Pathways		Antimicrobial peptides Formation of the cornified envelope	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Copper
Diseases			Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		5 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN	21 interacting genes: CALB2 CSTA DSP EVPL F12 FANCA FANCC IVL KNG1 KRT15 KRT33B KRT5 LINC00839 LORICRIN MBL2 NINL PDE4DIP PI3 PRKCE UBE3A YWHAQ
Entrez ID		5266	3848
HPRD ID		15947	00763
Ensembl ID		ENSG00000124102	ENSG00000167768
Uniprot IDs		P19957	P04264
PDB IDs		1FLE 2REL 6ATU	4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?