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FZR1 and TEAD2
Number of citations of the paper that reports this interaction (PubMedID
28205554
)
32
Data Source:
BioGRID
(fluorescent resonance energy transfer)
FZR1
TEAD2
Description
fizzy and cell division cycle 20 related 1
TEA domain transcription factor 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nuclear Membrane
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytosol
Intracellular Membrane-bounded Organelle
TEAD-2-YAP Complex
Molecular Function
Protein Binding
Anaphase-promoting Complex Binding
Ubiquitin-protein Transferase Activator Activity
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Factor Activity
Transcription Coregulator Activity
Protein Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Protein Heterodimerization Activity
Disordered Domain Specific Binding
Biological Process
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Positive Regulation Of Cell Proliferation
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Meiotic Nuclear Division
Positive Regulation Of Protein Catabolic Process
Cell Division
Lens Fiber Cell Differentiation
Protein K11-linked Ubiquitination
Signal Transduction Involved In G2 DNA Damage Checkpoint
Negative Regulation Of Cell Aging
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Vasculogenesis
Neural Tube Closure
Embryonic Heart Tube Morphogenesis
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Notochord Development
Hippo Signaling
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Development
Lateral Mesoderm Development
Embryonic Organ Development
Negative Regulation Of Cell Death
Protein-containing Complex Assembly
Cellular Response To Retinoic Acid
Regulation Of Stem Cell Differentiation
Pathways
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by VENTX
Antigen processing: Ubiquitination & Proteasome degradation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS
Interacting Genes
94 interacting genes:
AKT1
AKT1S1
ANAPC1
ANAPC10
ANAPC11
ANAPC2
ANAPC5
ANAPC7
ARNT
AURKA
BECN1
BEX1
BLID
BTRC
BUB1B
C7orf25
CCL5
CCNB1
CCND2
CCNE1
CCNF
CDC14A
CDC20
CDC25A
CDC27
CDC6
CDK2
CDK4
CDK5
CDK6
CDKN2A
CDKN2B
CDR2
CDT1
CLSPN
CYP17A1
DCPS
DKK3
DNAJA1
DNM1L
E2F3
EPHA2
EPSTI1
ERBB2
FBXO5
FGFR4
GLIS2
GMNN
HECW2
HIF1A
KAT2A
KIF18B
LATS2
MAD2L2
MAK
MAP2K3
MAP2K5
MAP3K5
MAPK8
MET
MOAP1
MTA3
MYC
NAT2
NEDD9
NEK2
NF2
OTUD7B
PAX3
PCLAF
PDGFRA
PLK1
PSMC3IP
PTP4A3
PTTG1
RASSF1
RBBP8
SENP2
SIRT2
SKIL
SKP2
SMURF1
SOX2
SOX4
STK11
TEAD2
TERT
THRSP
TP53
UBE2C
UBE2D1
UBE2D3
UBE2K
UBE2S
37 interacting genes:
AKT1
ARNT
AURKA
BCL2L15
BECN1
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
DACH1
EPHA2
FGFR4
FZR1
GLIS1
GLIS2
HGF
HIF1A
LATS2
MAP2K3
MAP2K5
MAP3K5
MYC
NCOA1
NEDD4
NFIC
NSD3
RAF1
RASSF1
SAA2
SOX3
STK11
TERT
TP53
USF2
VGLL1
YAP1
Entrez ID
51343
8463
HPRD ID
04687
03432
Ensembl ID
ENSG00000105325
ENSG00000074219
Uniprot IDs
Q9UM11
A0A024QZE2
Q15562
PDB IDs
4UI9
5L9T
5L9U
3L15
5DQ8
5DQE
5EMV
5HGU
6E5G
Enriched GO Terms of Interacting Partners
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