FZR1 and PCLAF

Number of citations of the paper that reports this interaction (PubMedID 21700221)
42

Data Source:
BioGRID (enzymatic study, pull down)

		FZR1	PCLAF
Description		fizzy and cell division cycle 20 related 1	PCNA clamp associated factor
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane	Nucleus Nucleoplasm Centrosome Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity	Chromatin Binding Protein Binding
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Cell Proliferation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Division Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint Negative Regulation Of Cell Aging Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	DNA Replication Cellular Response To DNA Damage Stimulus Centrosome Cycle Response To UV Translesion Synthesis Regulation Of Cell Cycle
Pathways		Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation	Termination of translesion DNA synthesis
Drugs
Diseases
GWAS
Interacting Genes		94 interacting genes: AKT1 AKT1S1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC5 ANAPC7 ARNT AURKA BECN1 BEX1 BLID BTRC BUB1B C7orf25 CCL5 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC20 CDC25A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2A CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PCLAF PDGFRA PLK1 PSMC3IP PTP4A3 PTTG1 RASSF1 RBBP8 SENP2 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 STK11 TEAD2 TERT THRSP TP53 UBE2C UBE2D1 UBE2D3 UBE2K UBE2S	1 interacting genes: FZR1
Entrez ID		51343	9768
HPRD ID		04687	13778
Ensembl ID		ENSG00000105325	ENSG00000166803
Uniprot IDs		Q9UM11	Q15004
PDB IDs		4UI9 5L9T 5L9U	4D2G 6EHT 6GWS 6IIW
Enriched GO Terms of Interacting Partners?
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