PCSK1 and IAPP

Number of citations of the paper that reports this interaction (PubMedID 3053705)
41

Data Source:
HPRD (in vitro, in vivo)

		PCSK1	IAPP
Description		proprotein convertase subtilisin/kexin type 1	islet amyloid polypeptide
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Secretory Granule Lumen Neuron Projection	Extracellular Region Extracellular Space Cell Neuronal Cell Body
	Molecular Function	Serine-type Endopeptidase Activity Identical Protein Binding	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Peptide Biosynthetic Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Mitochondrion Organization Sensory Perception Of Pain Negative Regulation Of Protein Complex Assembly Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Kinase B Signaling Amylin Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation
Pathways		Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation
Drugs		Insulin Human Insulin Pork	Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 24861553 28892062 25673413 29273807) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Glycemic traits (pregnancy) ( 23903356) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Waist circumference ( 23966867)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		4 interacting genes: IAPP PCSK1N PMCH REN	6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2
Entrez ID		5122	3375
HPRD ID		01201	01005
Ensembl ID		ENSG00000175426	ENSG00000121351
Uniprot IDs		P29120	A0A024RAU1 P10997
PDB IDs			1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ
Enriched GO Terms of Interacting Partners?
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