CHCHD2 and LHX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CHCHD2	LHX4
Description		coiled-coil-helix-coiled-coil-helix domain containing 2	LIM homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Intermembrane Space	Nuclear Chromatin Nucleus
	Molecular Function	Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Hypoxia	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Mitochondrial protein import	Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Metabolite levels ( 23823483 31628463) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
Interacting Genes		13 interacting genes: ADAMTSL4 EHMT2 FBXO7 GOLGA2 IKZF3 INCA1 KRT31 KRT40 LHX4 REL TCF4 TREX1 TRIM54	22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2
Entrez ID		51142	89884
HPRD ID		09879	03686
Ensembl ID		ENSG00000106153	ENSG00000121454
Uniprot IDs		Q9Y6H1	A0A0S2Z5S4 Q969G2
PDB IDs			5HOD
Enriched GO Terms of Interacting Partners?
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