LHX4 and SH2D1A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		LHX4	SH2D1A
Description		LIM homeobox 4	SH2 domain containing 1A
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response
Pathways		Regulation of expression of SLITs and ROBOs	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes		22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2	26 interacting genes: ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB3 FYB1 FYN GRB2 LCK LETMD1 LHX4 LY9 MAPK11 MAPK14 NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		89884	4068
HPRD ID		03686	02390
Ensembl ID		ENSG00000121454	ENSG00000183918
Uniprot IDs		A0A0S2Z5S4 Q969G2	O60880
PDB IDs		5HOD	1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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