LHX4 and LONRF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LHX4	LONRF1
Description		LIM homeobox 4	LON peptidase N-terminal domain and ring finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Metal Ion Binding
	Biological Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Protein Polyubiquitination
Pathways		Regulation of expression of SLITs and ROBOs	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Colorectal cancer (diet interaction) ( 24743840)
Interacting Genes		22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2	33 interacting genes: ADAMTSL4 ALAS1 ATG9A BRCA1 BYSL CALCOCO2 CRX EFHC2 GORASP1 GORASP2 HSPB1 IHO1 IKZF2 IQCF2 KAT5 KCTD9 KRT31 KRTAP13-1 LHX4 NR4A1 NTAQ1 PLSCR1 RBPMS SFN SPRY2 STAU1 STX11 TRIM42 TRIM9 UBE2L6 UCHL3 USP2 XIAP
Entrez ID		89884	91694
HPRD ID		03686	08674
Ensembl ID		ENSG00000121454	ENSG00000154359
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q17RB8
PDB IDs		5HOD
Enriched GO Terms of Interacting Partners?
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