RRM2B and RRM2

Number of citations of the paper that reports this interaction (PubMedID 14729598)
25

Data Source:
HPRD (in vitro)

		RRM2B	RRM2
Description		ribonucleotide reductase regulatory TP53 inducible subunit M2B	ribonucleotide reductase regulatory subunit M2
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Identical Protein Binding Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Protein Homodimerization Activity
	Biological Process	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Response To Amine Nucleobase-containing Small Molecule Interconversion Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Protein Heterotetramerization Oxidation-reduction Process Negative Regulation Of G0 To G1 Transition
Pathways		Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs		Cladribine	Cladribine Imexon Gallium nitrate motexafin gadolinium GTI 2040
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Blood protein levels ( 30072576 29875488) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010)	Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)
Interacting Genes		8 interacting genes: CDKN1A MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53	8 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B TP53
Entrez ID		50484	6241
HPRD ID		05276	01587
Ensembl ID		ENSG00000048392	ENSG00000171848
Uniprot IDs		Q7LG56	P31350
PDB IDs		2VUX 3HF1 4DJN	2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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