CCN3 and ADSL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CCN3	ADSL
Description		cellular communication network factor 3	adenylosuccinate lyase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Gap Junction Axon Dendrite Extracellular Matrix Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Cytosol Protein-containing Complex
	Molecular Function	Notch Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) Activity Identical Protein Binding (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) Activity
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Death Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration	Response To Hypoxia Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Response To Nutrient Aerobic Respiration Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Muscle Activity Response To Starvation 'de Novo' AMP Biosynthetic Process
Pathways			Purine ribonucleoside monophosphate biosynthesis
Drugs		Insulin Human Insulin Pork
Diseases			Adenylosuccinate lyase deficiency
GWAS			Body mass index ( 26426971) Height ( 19570815) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		14 interacting genes: ADSL CCN2 CDKN1A DLL1 FBLN1 FN1 GJA1 IGF1 IGF2 INS ITGAV NOTCH1 POLR2L S100A4	3 interacting genes: CALCOCO2 CCN3 REL
Entrez ID		4856	158
HPRD ID		01291	00049
Ensembl ID		ENSG00000136999	ENSG00000239900
Uniprot IDs		A0A024R9J4 P48745	P30566 X5D7W4 X5D8S6
PDB IDs			2J91 2VD6 4FFX 4FLC
Enriched GO Terms of Interacting Partners?
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