ADSL and CCN3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ADSL	CCN3
Description		adenylosuccinate lyase	cellular communication network factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Extracellular Region Cytoplasm Gap Junction Axon Dendrite Extracellular Matrix Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix
	Molecular Function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) Activity Identical Protein Binding (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) Activity	Notch Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding
	Biological Process	Response To Hypoxia Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Response To Nutrient Aerobic Respiration Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Muscle Activity Response To Starvation 'de Novo' AMP Biosynthetic Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Death Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs			Insulin Human Insulin Pork
Diseases		Adenylosuccinate lyase deficiency
GWAS		Body mass index ( 26426971) Height ( 19570815) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		3 interacting genes: CALCOCO2 CCN3 REL	14 interacting genes: ADSL CCN2 CDKN1A DLL1 FBLN1 FN1 GJA1 IGF1 IGF2 INS ITGAV NOTCH1 POLR2L S100A4
Entrez ID		158	4856
HPRD ID		00049	01291
Ensembl ID		ENSG00000239900	ENSG00000136999
Uniprot IDs		P30566 X5D7W4 X5D8S6	A0A024R9J4 P48745
PDB IDs		2J91 2VD6 4FFX 4FLC
Enriched GO Terms of Interacting Partners?
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