ADSL and CALCOCO2

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		ADSL	CALCOCO2
Description		adenylosuccinate lyase	calcium binding and coiled-coil domain 2
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GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) Activity Identical Protein Binding (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) Activity	Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Response To Hypoxia Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Response To Nutrient Aerobic Respiration Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Muscle Activity Response To Starvation 'de Novo' AMP Biosynthetic Process	Viral Process Response To Interferon-gamma Xenophagy Positive Regulation Of Autophagosome Maturation
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs
Diseases		Adenylosuccinate lyase deficiency
GWAS		Body mass index ( 26426971) Height ( 19570815) Regular attendance at a pub or social club ( 29970889)	Blood protein levels ( 30072576) Chronotype ( 30696823) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		3 interacting genes: CALCOCO2 CCN3 REL	150 interacting genes: ABLIM1 ADSL AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 AXIN1 BAHD1 BCL6B BEX2 CBX8 CCDC185 CCDC33 CCNH CEP57L1 CHCHD3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 ELOA2 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FNDC11 FXR2 GABARAPL1 GABARAPL2 GATAD2B GEMIN4 GIT2 GLYCTK HDAC7 HLX HNRNPLL HOXB9 IKBKG KANSL1 KAT7 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAVS MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAB2 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SDCBP SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STK16 TBC1D22B TBK1 TBRG4 TCL1A TEKT3 TENT2 TLE5 TP53RK TRAF2 TRAF4 TRAF6 TTC23L UBAC2 VARS1 VPS72 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF688
Entrez ID		158	10241
HPRD ID		00049	06846
Ensembl ID		ENSG00000239900	ENSG00000136436
Uniprot IDs		P30566 X5D7W4 X5D8S6	Q13137
PDB IDs		2J91 2VD6 4FFX 4FLC	2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L
Enriched GO Terms of Interacting Partners?
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