NEK1 and LRRK1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
4

Data Source:
BioGRID (pull down)

		NEK1	LRRK1
Description		NIMA related kinase 1	leucine rich repeat kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Centriolar Satellite	Mitochondrion Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding 14-3-3 Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity DNA Damage Response, Detection Of DNA Damage Cell Division Cilium Assembly	Protein Phosphorylation Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases		Short rib-polydactyly syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Night sleep phenotypes ( 27126917) Schizophrenia ( 28991256 25056061 29483656) Supramarginal gyrus volume ( 31530798)	Central corneal thickness ( 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)
Interacting Genes		18 interacting genes: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD SIRPA TP53BP1 TSC2 YWHAH ZNF350	53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SELENOS SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP TM2D3 VGLL4
Entrez ID		4750	79705
HPRD ID		06847	14319
Ensembl ID		ENSG00000137601	ENSG00000154237
Uniprot IDs		Q5JXL9 Q96PY6	Q38SD2
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?