MYBL2 and LIN52

Number of citations of the paper that reports this interaction (PubMedID 17671431)
84

Data Source:
BioGRID (pull down, affinity chromatography technology)

		MYBL2	LIN52
Description		MYB proto-oncogene like 2	lin-52 DREAM MuvB core complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Myb Complex	Nucleoplasm DRM Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Mitotic Spindle Assembly Cellular Response To Leukemia Inhibitory Factor	Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Polo-like kinase mediated events TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS			Blood protein levels ( 28240269) Chronotype ( 30696823) Macular thickness ( 30535121) Waist-hip ratio ( 28552196)
Interacting Genes		31 interacting genes: CCNA1 CCNA2 CCND1 CCNE1 CCNF CDC34 CDK2 CDK9 CREBBP CXCR4 E2F1 E2F3 EP300 LIN52 LIN9 LZTR1 MAP1LC3B MAPK6 NCOR1 NCOR2 PARP1 RBBP4 RBL1 SKP2 SND1 TRIM15 TTF2 UBB UBE2D4 ZBTB9 ZNF622	5 interacting genes: DYRK1A MYBL2 NEK9 RBBP4 RBL2
Entrez ID		4605	91750
HPRD ID		03247	18708
Ensembl ID		ENSG00000101057	ENSG00000205659
Uniprot IDs		P10244	B3KN83 Q52LA3
PDB IDs		6C48	4YOO 6C48
Enriched GO Terms of Interacting Partners?
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