MYBL2 and E2F3

Number of citations of the paper that reports this interaction (PubMedID 12748276)
45

Data Source:
BioGRID (two hybrid)

		MYBL2	E2F3
Description		MYB proto-oncogene like 2	E2F transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Myb Complex	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding Bacterial-type RNA Polymerase Transcriptional Activator Activity, Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Mitotic Spindle Assembly Cellular Response To Leukemia Inhibitory Factor	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Import Into Nucleus Positive Regulation Of Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Polo-like kinase mediated events TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence CDC6 association with the ORC:origin complex G2 Phase Cyclin D associated events in G1
Drugs
Diseases
GWAS			Estimated glomerular filtration rate in non-diabetics ( 31451708) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Obesity-related traits ( 23251661)
Interacting Genes		31 interacting genes: CCNA1 CCNA2 CCND1 CCNE1 CCNF CDC34 CDK2 CDK9 CREBBP CXCR4 E2F1 E2F3 EP300 LIN52 LIN9 LZTR1 MAP1LC3B MAPK6 NCOR1 NCOR2 PARP1 RBBP4 RBL1 SKP2 SND1 TRIM15 TTF2 UBB UBE2D4 ZBTB9 ZNF622	25 interacting genes: ATAD2 CCNA2 CDK3 CREBBP DNMT3L FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 UCHL5 WNK1 YY1
Entrez ID		4605	1871
HPRD ID		03247	02693
Ensembl ID		ENSG00000101057	ENSG00000112242
Uniprot IDs		P10244	O00716
PDB IDs		6C48
Enriched GO Terms of Interacting Partners?
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