TRIM37 and DDX6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRIM37	DDX6
Description		tripartite motif containing 37	DEAD-box helicase 6
Image
GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Heterochromatin P-body Outer Dense Fiber Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly	Viral RNA Genome Packaging Stem Cell Population Maintenance Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Neuron Differentiation Spermatid Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	mRNA decay by 5' to 3' exoribonuclease
Drugs			D-tartaric acid
Diseases
GWAS		Cognitive function ( 25644384) General cognitive ability ( 29844566) Testicular germ cell tumor ( 23666239)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 30929738 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469 19838195) Systemic sclerosis ( 24387989 31672989) Vitiligo ( 22951725)
Interacting Genes		63 interacting genes: ANKRD11 APEX2 APTX ARNT2 AXIN1 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655	29 interacting genes: BEND7 BIRC7 CALCOCO2 CEP70 CNOT1 EDC3 EIF4ENIF1 ENTR1 GOLGA2 IKZF1 KLC4 KRT40 KRTAP10-3 KRTAP10-8 NONO PNMA5 RBM14 RUNDC3A SIPA1L2 SRPK2 STAT1 TCF4 TLE5 TRIM27 TRIM37 U2AF2 VPS52 ZBTB8A ZNF24
Entrez ID		4591	1656
HPRD ID		05463	02638
Ensembl ID		ENSG00000108395	ENSG00000110367
Uniprot IDs		O94972	B2R858 P26196
PDB IDs		3LRQ	1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?
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