MSH3 and MSH2

Number of citations of the paper that reports this interaction (PubMedID 8942985)
155

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MSH3	MSH2
Description		mutS homolog 3	mutS homolog 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSbeta Complex	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSalpha Complex MutSbeta Complex
	Molecular Function	Single-stranded DNA Binding Protein Binding DNA-dependent ATPase Activity Enzyme Binding Mismatched DNA Binding DNA Insertion Or Deletion Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity	Magnesium Ion Binding Four-way Junction DNA Binding Double-strand/single-strand DNA Junction Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Meiotic Mismatch Repair Removal Of Nonhomologous Ends DNA Repair Mismatch Repair Mitotic Recombination Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Replication Fork Arrest Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair DNA Recombination Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Helicase Activity Protein Localization To Chromatin
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases		Colorectal cancer	Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Ovarian cancer
GWAS		HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124)	Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		13 interacting genes: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 TSC22D2 XPA	33 interacting genes: AKT1 ANXA7 ATR BARD1 BRCA1 CDKN1A CHEK2 CREBBP EPHA2 ESR1 ESR2 EXO1 FGFR4 GRB7 HDAC6 HUS1 MAX MSH3 MSH6 MYC PCNA RAD1 RAD9A RPA4 RPP14 SMC1A SMN1 SUMO2 TK1 TREX1 TRIM29 USP10 XPA
Entrez ID		4437	4436
HPRD ID		02931	00389
Ensembl ID		ENSG00000113318	ENSG00000095002
Uniprot IDs		P20585	A0A2R8Y6P0 P43246
PDB IDs		3THW 3THX 3THY 3THZ	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
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