MSH3 and RPA4

Number of citations of the paper that reports this interaction (PubMedID 19468048)
38

Data Source:
BioGRID (pull down)

		MSH3	RPA4
Description		mutS homolog 3	replication protein A4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSbeta Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break
	Molecular Function	Single-stranded DNA Binding Protein Binding DNA-dependent ATPase Activity Enzyme Binding Mismatched DNA Binding DNA Insertion Or Deletion Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity	Single-stranded DNA Binding
	Biological Process	Meiotic Mismatch Repair Removal Of Nonhomologous Ends DNA Repair Mismatch Repair Mitotic Recombination Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Replication Fork Arrest Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation DNA Repair Nucleotide-excision Repair Nuclear DNA Replication
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2	Activation of the pre-replicative complex
Drugs
Diseases		Colorectal cancer
GWAS		HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124)
Interacting Genes		13 interacting genes: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 TSC22D2 XPA	7 interacting genes: APP MSH2 MSH3 MUTYH RPA1 RPA3 XPA
Entrez ID		4437	29935
HPRD ID		02931	06591
Ensembl ID		ENSG00000113318	ENSG00000204086
Uniprot IDs		P20585	Q13156
PDB IDs		3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
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