MSH2 and RPA4

Number of citations of the paper that reports this interaction (PubMedID 19468048)
38

Data Source:
BioGRID (pull down)

		MSH2	RPA4
Description		mutS homolog 2	replication protein A4
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSalpha Complex MutSbeta Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Double-strand/single-strand DNA Junction Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding	Single-stranded DNA Binding
	Biological Process	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair DNA Recombination Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Helicase Activity Protein Localization To Chromatin	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation DNA Repair Nucleotide-excision Repair Nuclear DNA Replication
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes	Activation of the pre-replicative complex
Drugs
Diseases		Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Ovarian cancer
GWAS		Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		33 interacting genes: AKT1 ANXA7 ATR BARD1 BRCA1 CDKN1A CHEK2 CREBBP EPHA2 ESR1 ESR2 EXO1 FGFR4 GRB7 HDAC6 HUS1 MAX MSH3 MSH6 MYC PCNA RAD1 RAD9A RPA4 RPP14 SMC1A SMN1 SUMO2 TK1 TREX1 TRIM29 USP10 XPA	7 interacting genes: APP MSH2 MSH3 MUTYH RPA1 RPA3 XPA
Entrez ID		4436	29935
HPRD ID		00389	06591
Ensembl ID		ENSG00000095002	ENSG00000204086
Uniprot IDs		A0A2R8Y6P0 P43246	Q13156
PDB IDs		2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
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