MMP16 and KISS1

Number of citations of the paper that reports this interaction (PubMedID 12879005)
29

Data Source:
HPRD (in vivo, in vitro)

		MMP16	KISS1
Description		matrix metallopeptidase 16	KiSS-1 metastasis suppressor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Matrix	Extracellular Region Extracellular Space Cell Cytoplasm Apical Plasma Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Metalloaminopeptidase Activity	Protein Binding Kisspeptin Receptor Binding
	Biological Process	Skeletal System Development Endochondral Ossification Proteolysis Protein Processing Protein Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Positive Regulation Of Catalytic Activity Embryonic Cranial Skeleton Morphogenesis Craniofacial Suture Morphogenesis	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Proliferation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Generation Of Ovulation Cycle Rhythm Positive Regulation Of Growth Hormone Secretion
Pathways		Activation of Matrix Metalloproteinases	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Marimastat Batimastat
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Cerebral amyloid deposition (PET imaging) ( 26252872) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Heel bone mineral density ( 30598549) Irritable mood ( 29500382) Migraine without aura ( 23793025) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872) Sweet taste perception in obesity with metabolic syndrome ( 31005965)	Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		2 interacting genes: KISS1 LRP1	8 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9
Entrez ID		4325	3814
HPRD ID		03776	04475
Ensembl ID		ENSG00000156103	ENSG00000170498
Uniprot IDs		P51512	Q15726
PDB IDs		1RM8
Enriched GO Terms of Interacting Partners?
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