KISS1 and MMP16

Number of citations of the paper that reports this interaction (PubMedID 12879005)
29

Data Source:
HPRD (in vivo, in vitro)

		KISS1	MMP16
Description		KiSS-1 metastasis suppressor	matrix metallopeptidase 16
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cytoplasm Apical Plasma Membrane Neuron Projection Neuronal Cell Body	Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Matrix
	Molecular Function	Protein Binding Kisspeptin Receptor Binding	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Metalloaminopeptidase Activity
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Proliferation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Generation Of Ovulation Cycle Rhythm Positive Regulation Of Growth Hormone Secretion	Skeletal System Development Endochondral Ossification Proteolysis Protein Processing Protein Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Positive Regulation Of Catalytic Activity Embryonic Cranial Skeleton Morphogenesis Craniofacial Suture Morphogenesis
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Activation of Matrix Metalloproteinases
Drugs			Marimastat Batimastat
Diseases
GWAS		Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Cerebral amyloid deposition (PET imaging) ( 26252872) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Heel bone mineral density ( 30598549) Irritable mood ( 29500382) Migraine without aura ( 23793025) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872) Sweet taste perception in obesity with metabolic syndrome ( 31005965)
Interacting Genes		8 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9	2 interacting genes: KISS1 LRP1
Entrez ID		3814	4325
HPRD ID		04475	03776
Ensembl ID		ENSG00000170498	ENSG00000156103
Uniprot IDs		Q15726	P51512
PDB IDs			1RM8
Enriched GO Terms of Interacting Partners?
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