KISS1 and KISS1R

Number of citations of the paper that reports this interaction (PubMedID 11457843)
288

Data Source:
HPRD (in vivo, in vitro)

		KISS1	KISS1R
Description		KiSS-1 metastasis suppressor	KISS1 receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cytoplasm Apical Plasma Membrane Neuron Projection Neuronal Cell Body	Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Kisspeptin Receptor Binding	Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Proliferation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Generation Of Ovulation Cycle Rhythm Positive Regulation Of Growth Hormone Secretion	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases			Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP) Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Menopause (age at onset) ( 26414677)
Interacting Genes		8 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9	3 interacting genes: KISS1 PPP2CA PTPA
Entrez ID		3814	84634
HPRD ID		04475	09167
Ensembl ID		ENSG00000170498	ENSG00000116014
Uniprot IDs		Q15726	Q969F8 U3KQ86
PDB IDs
Enriched GO Terms of Interacting Partners?
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