MICB and KLRK1

Number of citations of the paper that reports this interaction (PubMedID 12902493)
11

Data Source:
HPRD (in vitro)

		MICB	KLRK1
Description		MHC class I polypeptide-related sequence B	killer cell lectin like receptor K1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Natural Killer Cell Lectin-like Receptor Binding	Protein Binding Carbohydrate Binding MHC Class Ib Receptor Activity Signaling Receptor Activity MHC Class I Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Response To Oxidative Stress Response To Heat Viral Process Cytolysis Response To Retinoic Acid Gamma-delta T Cell Activation Negative Regulation Of Defense Response To Virus By Host Regulation Of Immune Response	Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Positive Regulation Of Interferon-gamma Production Negative Regulation Of GTPase Activity Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Defense Response To Gram-positive Bacterium Cellular Response To Lipopolysaccharide Negative Regulation Of Natural Killer Cell Chemotaxis
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Alcohol use disorder ( 30940813) Allergic sensitization ( 23817571) Arterial stiffness index ( 31235810) Asthma ( 31619474 29273806) Asthma (childhood onset) ( 31619474 29273806) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Behcet's disease ( 23001997) Blood protein levels ( 30072576 29875488 28240269) Cervical cancer ( 28806749) Cold sores ( 28928442) Crohn's disease ( 23128233) Cutaneous lupus erythematosus ( 25827949) Dengue shock syndrome ( 22001756) Handedness (non-right-handed vs right-handed) ( 31504236) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 28067908) Metabolic syndrome ( 22399527) Midgestational circulating levels of PBDEs ( 28235828) Monocyte count ( 27863252) Mononucleosis ( 28928442) Myositis ( 26291516) Oral cavity cancer ( 27749845) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Plateletcrit ( 27863252) Pneumonia ( 28928442) Psychosis (atypical) ( 24132900) Pulmonary function ( 21946350) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Ulcerative colitis ( 28067908)	Blood protein levels ( 28240269) Interleukin-1-receptor antagonist levels ( 22205395) Obesity-related traits ( 23251661) Psoriasis ( 28537254)
Interacting Genes		2 interacting genes: KLRC4 KLRK1	7 interacting genes: HCST MICB RAE1 RAET1E RAET1G TYROBP ULBP3
Entrez ID		4277	22914
HPRD ID		03894	17240
Ensembl ID		ENSG00000204516	ENSG00000213809
Uniprot IDs		A0A0G2JHB5 B4DUT9 B7Z8M1 F5H7Q8 Q29980 X6R344	A0A024RAP8 P26718
PDB IDs		1JE6 2WY3	1HYR 1KCG 1MPU 4PDC 4S0U
Enriched GO Terms of Interacting Partners?
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