LORICRIN and KRT1

Number of citations of the paper that reports this interaction (PubMedID 8999895)
28

Data Source:
BioGRID (pull down)

		LORICRIN	KRT1
Description		loricrin cornified envelope precursor protein	keratin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleoplasm Cytoplasm Cytosol	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Epidermis	Protein Binding Carbohydrate Binding Structural Constituent Of Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Cytoskeleton Organization Peptide Cross-linking Keratinocyte Differentiation Cornification	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification
Pathways		Formation of the cornified envelope	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Copper
Diseases		Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis	Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS
Interacting Genes		7 interacting genes: CSTA EVPL IVL KRT1 PI3 SPRR3 VIM	21 interacting genes: CALB2 CSTA DSP EVPL F12 FANCA FANCC IVL KNG1 KRT15 KRT33B KRT5 LINC00839 LORICRIN MBL2 NINL PDE4DIP PI3 PRKCE UBE3A YWHAQ
Entrez ID		4014	3848
HPRD ID		01070	00763
Ensembl ID		ENSG00000203782	ENSG00000167768
Uniprot IDs		P23490	P04264
PDB IDs			4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
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