CRADD and ACTN2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		CRADD	ACTN2
Description		CASP2 and RIPK1 domain containing adaptor with death domain	actinin alpha 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding	Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	MAPK Cascade Platelet Degranulation Cell Adhesion Microspike Assembly Muscle Filament Sliding Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Focal Adhesion Assembly Actin Filament Uncapping Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Regulation Of NMDA Receptor Activity Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases	Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		20 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN WIF1	86 interacting genes: ACTN1 ACTN3 ADAM12 ADORA2A AKAP8L ANG ANGPTL7 ATP5MC1 ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 CD27 CLEC4D COIL CRABP2 CRADD DISC1 DLG1 DLG4 EPS8L1 ERBIN FAM50B FBXL22 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MRPL10 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 PPP1CB QARS1 RACK1 RAVER1 RPL35 RTP5 SAXO1 SELE SNAI1 SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 TCTEX1D2 TNN TOLLIP TTN UTRN ZC2HC1C ZNF446 ZNRD2
Entrez ID		8738	88
HPRD ID		04584	00019
Ensembl ID		ENSG00000169372	ENSG00000077522
Uniprot IDs		B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43	F6THM6 P35609 Q59FD9
PDB IDs		2O71 2OF5 3CRD	1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B
Enriched GO Terms of Interacting Partners?
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