USP1 and TRIM46

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		USP1	TRIM46
Description		ubiquitin specific peptidase 1	tripartite motif containing 46
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoskeleton Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Thiol-dependent Ubiquitinyl Hydrolase Activity	Zinc Ion Binding
	Biological Process	Skeletal System Development Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage	Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Cellular Protein Localization
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway	Interferon gamma signaling
Drugs
Diseases
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Metabolic syndrome ( 31589552) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Serum uric acid levels ( 30993211) Urate levels ( 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		12 interacting genes: DTX3 FANCD2 FANCI KLHDC2 KPNA1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K	20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32
Entrez ID		7398	80128
HPRD ID		04593	15563
Ensembl ID		ENSG00000162607	ENSG00000163462
Uniprot IDs		O94782	A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8
PDB IDs		6DO5
Enriched GO Terms of Interacting Partners?
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