KIR2DL4 and TRIP6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KIR2DL4	TRIP6
Description		killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	thyroid hormone receptor interactor 6
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Early Endosome Membrane	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity	RNA Binding Interleukin-1 Receptor Binding Protein Binding Kinase Binding Metal Ion Binding Thyroid Hormone Receptor Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Cellular Senescence	Signal Transduction Positive Regulation Of Cell Migration Chordate Embryonic Development Focal Adhesion Assembly Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Objective response to lithium treatment ( 26503763)	Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Interacting Genes		5 interacting genes: FCER1G HLA-G RBPMS RNF216 TRIP6	112 interacting genes: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP23 ATP5PO ATXN1 AXIN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CRYBA4 CTAG2 DHX37 DMRT3 DTX2 EFHC1 EXOC3-AS1 FAM124B FASLG FHL3 FRS3 GAD1 GATA1 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK IL16 ILF3 INCA1 IQCN KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NOL4L-DT NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SAXO1 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 TENT5C THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS YPEL3 ZBP1 ZNF688
Entrez ID		3805	7205
HPRD ID		16082	04242
Ensembl ID		ENSG00000189013	ENSG00000087077
Uniprot IDs		A0A0B4J1S6 A0A376A929 Q99706	Q15654
PDB IDs		3WYR	1X61 2DLO
Enriched GO Terms of Interacting Partners?
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