KIR2DL4 and FCER1G

Number of citations of the paper that reports this interaction (PubMedID 15778339)
46

Data Source:
HPRD (in vivo)

		KIR2DL4	FCER1G
Description		killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Fc fragment of IgE receptor Ig
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Early Endosome Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity	Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Cellular Senescence	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Stimulatory C-type Lectin Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Osteoclast Differentiation Neutrophil Chemotaxis Receptor Internalization Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Positive Regulation Of Mast Cell Degranulation Neutrophil Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Leukocyte Migration Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen
Drugs			Benzylpenicilloyl Polylysine
Diseases
GWAS		Objective response to lithium treatment ( 26503763)	Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)
Interacting Genes		5 interacting genes: FCER1G HLA-G RBPMS RNF216 TRIP6	9 interacting genes: FCER1A FCGR3A GP6 KIR2DL4 LMNA LYN NCR1 PLCG2 SYK
Entrez ID		3805	2207
HPRD ID		16082	00916
Ensembl ID		ENSG00000189013	ENSG00000158869
Uniprot IDs		A0A0B4J1S6 A0A376A929 Q99706	P30273
PDB IDs		3WYR
Enriched GO Terms of Interacting Partners?
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